We are not supporting this browser

European guidelines for feeding preterm infants

What are the ESPGHAN nutritional guidelines?

The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) is a multi-professional organisation set up to promote the health of children.

ESPGHAN’s nutritional guidelines offer comprehensive and practical advice on the feeding of preterm infants1. Their goal is to ensure that infants who are born prematurely receive all the nutrients needed to achieve optimal growth and development. The guidelines offer recommendations on the required intakes of specific nutrients needed by infants up to a weight of 1800g. They also offer some practical advice on how these nutrient requirements can be achieved.

Why did we need new guidelines?

Over the past 20 years the survival of preterm infants has improved substantially. Neonatal teams are now caring for a growing number of infants likely to survive from an increasingly premature start to life. As experience of caring for these preterm infants has grown, so has our understanding of their specific nutritional needs. It was to reflect these changing demands that ESPGHAN decided to update the guidelines it had first published in 1987. The new guidelines recognise that preterm infants have different nutritional requirements depending on their weight and offer ideal intake ranges for each specific nutrient.

What do they say?

The guidelines state that the ‘preferred food for premature infants is fortified human milk from the infant’s own mother, or, alternatively, formula designed for premature infants’. Expressed breast milk should be supplemented where necessary by a breast milk fortifier (BMF). Where fortified breast milk or formula feeds are used their nutrient content should correspond as closely as possible to the ideal values shown in table 1.

Key ESPGHAN recommendations

  Daily intake per kg per day Per 100kcal
Fluid 135-200ml  
Energy 110-135kcal  
Protein <1kg bodyweight 4.0-4.5g 3.6-4.1g
Protein 1-1.8kg bodyweight 3.5-4.0g 3.2-3.6g
Lipids 4.8-6.6g 4.4-6.0g
Carbohydrate 11.6-13.2g 10.5-12g
Iron 2-3mg 1.8-2.7mg
Vitamin D 800-1000 IU/day  
Vitamin A 400-1000µg RE 360-740µg RE
Sodium 69-115mg 63-105mg
Selenium 5-10µg 4.5-9µg
Calcium 120-140mg 110-130mg
Phosphorus 60-90mg 55-80mg
Folic acid 35-100µg 32-90µg

Who should read the guidelines?

“A recent survey of 170 healthcare professionals revealed that 67.6% would like to know more about the ESPGHAN guidelines.”2

The ESPGHAN guidelines are aimed at all healthcare professionals involved in the nutrition of preterm infants.

It is particularly important that healthcare professionals who help mothers use BMF or formula milks are aware of the recommended levels of key nutrients so they can ensure that the decisions they make conform to these values.

How should the ESPGHAN guidelines affect my practice?

Proactive nutritional care

The ESPGHAN guidelines serve as a necessary reminder of the importance of nutrition for preterm infants. The emphasis is no longer on simply keeping vulnerable preterm infants alive, it is on ensuring the provision of adequate amounts of key nutrients to optimise short-term growth and development and long-term health.

The guidelines urge a proactive approach to the nutritional management of preterm infants, with close monitoring of their nutritional status. This nutritional status should not be allowed to drift across the percentile lines of growth charts before attempts are made to catch up. Preterm nutrition should be more about prevention than cure.

Multidisciplinary team

Preterm nutrition requires a multidisciplinary approach involving neonatologists, nursing staff, breast feeding advisors, dietitians, speech therapists and gastroenterologists. A coordinated, proactive approach to nutritional care should involve all of these staff.

Importance of breast milk

The guidelines stress the importance of human breast milk as the optimal feed for preterm infants. Supporting new mothers to express breast milk is fundamental to the care of these vulnerable infants.

Mothers and healthcare professionals should be aware that the composition of expressed preterm breast milk changes over time and even throughout the day. For instance, initial high quantities of protein and antibodies may decrease. Some women experience quite large variations in protein and energy content throughout the day. If facilities and time are available it may be possible to “pool” the mother’s milk, measure the protein and energy content and add BMF accordingly. Close monitoring of weight gain, longitudinal growth, head circumference, serum urea levels and bone profile will also alert healthcare professionals to the need for extra nutrients.

Appropriate strategies to optimise milk production include:

  • Ensuring information on how to express milk is available to all new mothers within six hours of birth, stressing the importance of early and frequent expressing
  • Providing access to suitable equipment including breast pumps
  • Providing guidance on equipment sterilisation and storage of expressed milk
  • Encouraging skin-to-skin contact with their infant
  • Ensuring ongoing support to maintain lactation and milk expression

Role of breast milk fortifier (BMF)

Adequate volumes of breast milk and additional vitamins will meet the nutritional needs of most preterm infants born at 1500g birth weight and above, due to greater amounts of protein and other nutrients in early preterm milk. These infants require close monitoring to ensure they are achieving satisfactory weight gain otherwise breast milk fortifier may need to be introduced.

Fortified breast milk should be considered for those infants born below 1500g birth weight in order to optimise growth and bone mineralization. Most infants will need fortification by two to three weeks of age, to compensate for the change in breast milk composition as it becomes closer to the nutritional profile of term breast milk.

Infants born below 1000g birth weight and before 30 weeks gestation are particularly vulnerable to feed intolerance and possible necrotising enterocolitis. Feed tolerance is achieved once the infant is no longer taking parenteral nutrition, is absorbing approximately 150ml/kg/day of milk, has minimal gastric aspirates and is passing regular stools. The timing of introduction of BMF is important. BMF can be commenced before full feeds are achieved although waiting until full feeds is common practice. Many neonatal teams introduce BMF gradually: some units will fortify alternate feeds for the first 24-48 hours, or use half strength fortification, although many find that commencing with full strength fortification results in acceptable tolerance.

Preterm formulas

Infants whose mothers are unable to continue to express milk (or who have chosen not to) should be fed a formula milk that is specifically designed for preterm infants and which meets the ESPGHAN guidelines. Normal term formulas will not meet the preterm infant’s nutritional needs.

  1. Agostoni C et al. Enteral Nutrient Supply for Preterm Infants: Commentary from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition J Pediatr Gastroenterol Nutr 2010;50(1):85–91.
  2. Danone Baby Nutrition. Caring for the Young: A Telephone Survey of Neonatal Healthcare Professionals. Opinion Matters. London 2011.

You may also be interested in

Nutricia uses cookies on this website. With your consent we will use them to measure and analyze usage of the website (analytical cookies), to tailor it to your interests (personalisational cookies), and to present you relevant advertising and information (targeting cookies). For more information please read the cookie policy.

Privacy Settings

You can choose your preferences anytime for cookies and tracking. For more information please read our cookie policy.

  • Strictly necessary

    They are necessary for the website to function and cannot be switched off. They are usually only set in response to actions made by you which amount to a request for services (setting your privacy preferences, logging in, filling in forms, etc.). You can set your browser to block or alert you about these cookies, but some parts of the site will not then work.

  • Analytical cookies

    They allow us to count visits and traffic sources, to measure and improve the performance of our site. They show us which pages are the most and least popular and how visitors move around the site. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.

  • Personalisation cookies

    They enable website’s enhanced functionality and personalisation. They may be set by us or by third parties whose services we have added to our pages. If you do not allow these cookies, some or all of these services may not function properly.

  • Targeting cookies

    They may be set through our site by our advertising partners, to build a profile of your interests and to show you relevant adverts on other sites. They do not store directly personal information, but are based on uniquely identifying your browser and internet device. If you do not allow these cookies, you will experience less targeted advertising.