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Neocate Syneo: The only AAF with pre- and probiotics

Nutrition during the first months of life has a significant influence on the development and composition of the gut microbiota1.

Research shows that allergic infants, including those with Cow's Milk Allergy and Multiple Food Protein Allergies (MFPA), have an inbalance in the gut microbiota profile known as 'dysbiosis'.1-3

Gut microbiota dysbiosis in early infancy may delay oral tolerance, which can play an important role in the development of immune related conditions such as food allergy and atopic dermatitis.4-10

Cow's Milk Allergy Microbiota Dysbiosis
Prebiotic, probiotic and synbiotic image
Prebiotic and probiotic in Neocate Syneo
ASSIGN clinical trial study

Neocate Syneo

Neocate Syneo is the only AAF that resolves cow’s milk allergy symptoms & helps restore gut microbiota16,17,23 to support long-term health and immunity1,24-27

  • The only AAF with pre- and probiotics (synbiotics) that are clinically proven to restore the gut microbiota of allergic infants16,23, bringing it closer to that of healthy breast fed infants16 
  • The addition of synbiotics brings Neocate Syneo closer to breast milk than any other AAF16,23 
  • Research shows that infants on Neocate Syneo exhibit fewer infections23,17, less use of antibiotics16,23 and use fewer dermatological medications23   
  • Proven results in infants with CMA, with over 10 years of research
  • Hypoallergenic23,17 – made with 100% free amino acids
  • Nutritionally complete28
  • Supports growth23,17

Important notice: Breastfeeding is best. Neocate Syneo is a food for special medical purposes for the dietary management of Cow’s Milk Allergy, Multiple Food Protein Allergies and other conditions where an amino acid based formula is recommended. It should only be used under medical supervision, after full consideration of the feeding options available including breastfeeding. Suitable for use as the sole source of nutrition for infants under one year of age. Refer to label for details.

  1. Wopereis H, et al. Pediatr Allergy Immunol. 2014;25:428-38. 
  2. Canani R et al. ISME J. 2016;(3)742-50. 
  3. Ling Z et al. Appl Environ Microbiol 2014;80:2546-54.
  4. Bisgaard, H et al. J Allergy Clin Immunol. 2011;128:646-52.e1-5. 
  5. Azad MB et al. Clin Exp Allergy. 2015;45:632-43. 
  6. Abrahamsson TR et al. J Allergy Clin Immunol. 2012;129:434-40, 40.e1-2.
  7. Pabst O & Mowat AM, Nature 2012;5(3):232-239. 
  8. Weiner L et al. Immunological Reviews 2011;24:241-259. 
  9. West CE et al. Clin Experimental Allergy;45:43-53. 
  10. Huang YJ et al. The Journal of Allergy and Clinical Immunology 2017;139(4):1099-1110. 
  11. Thompson-Chagoyan OC et al. Pediatr Allergy Immunol.2010;21:e394-400. 
  12. Roger LC et al. Microbiology. 2010;156:3317-28. 
  13. Scholtens PA, et al. J Nutr. 2008;138:1141-7. 
  14. Scholtens PA et al. Annu Rev Food Sci Technol 2012;3:21.1:21-23. 
  15. Harmsen H et al. JPGN 2000;30:61-67. 
  16. Candy et al. Pediatr Research, 2018;83(3):677-686. 
  17. Burks AW et al. Ped Allergy Immunol. 2015;26:316-22. 
  18. Gibson G. et al. Nat Rev Gastro Hepatology 2017;14:491–502. 
  19. Knol J et al. JPGN 2005;40:36-42. 
  20. Knol J et al. Acta Paediatr Suppl 2005;94:34-33. 
  21. Boehm G et al. Acta Paediatr 2005;94(supp449):18-21.
  22. Moro G et al. JPGN 2002;34:291-295.
  23. Harvey BM. et al. Pediatr. Research 2014;75(2):343-351 
  24. De Boissieu D, Matarazzo P, Dupont C. J Pediatr 1997;131(5):744-747. 
  25. Vanderhoof JA, Murray MD, Kaufman S et al. JPediatr 1997;131 (5):741-744
  26. Fox et al. Clin Transl Allergy. 2019;9:5. 
  27. Martin R et al. Benef Microbes. 2010;1(4):367-82. 
  28. Commission Directive 1999/21/EC (FSMP) and Commission Directive 2006/141/EC (as laid down in the infant formulae and follow-on formula guidelines)  

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