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Neocate Syneo

Only one Amino Acid formula (AAF) resolves Cow’s Milk Allergy (CMA) symptoms & helps restore gut microbiota1–3 to support long-term health and immunity5,6 




  • Neocate Syneo is the only AAF that contains synbiotics, a synergistic blend of pre- and probiotics1-3
  • Neocate Syneo has been shown to resolve CMA symptoms1-4 and restores the gut microbiota to be closer to that of a healthy breastfed infant1,2
  • Supporting the gut health of infants is important in supporting their long-term health and immunity5,6


Neocate: 35 years reinvesting into CMA research and innovation

>95 clinical studies published on Neocate and its use in CMA, multiple food protein allergy (MFPA) and other conditions requiring an amino acid-based diet.

Breast milk is the best source of nutrition for infants with CMA7,8

Nutrition during the first months of life has a significant influence on the development and composition of the gut microbiota.5 Research shows that the gut microbiota plays an important role in the development of the immune system.9

Breast milk contains all the essential nutrients to support an infant's growth and development. It contains pre- and probiotics to stimulate a healthy gut microbiota and support the developing immune system.10,11 Breastfeeding has been shown to reduce the risk of allergic disease.12,13

Breastfed infants benefit from the synergistic effect of prebiotic oligosaccharides and beneficial bacteria naturally present in breast milk

  • Supporting a healthy, diverse gut microbiota11,14,15
  • Promoting tolerance and developing the immune response10,16,17

Only Neocate Syneo contains synbiotics, bringing it closer to breast milk than any other AAF1

The synbiotics in Neocate Syneo have been developed through extensive research of pre- and probiotics and tested in allergic infants,1-4 who commonly have lower levels of Bifidobacteria than healthy infants.18–22

Synbiotics are a patented combination of pre- and probiotics in a synergistic relationship.

Evidence shows that synbiotics positively influence the gut microbiota of allergic infants, bringing it closer to that of a healthy breastfed infant.1

Neocate Syneo is the only AAF with consistent high-quality evidence in cow’s milk allergic infants, the intended patient group1-4,34

Supported by randomised clinical trials, Neocate Syneo has shown unique benefits supported by extensive research:

  • Brings the gut microbiota closer to that of healthy breastfed infants (ASSIGN) 1-3
  • Is hypoallergenic and well tolerated3,4
  • Fewer reported infections and less antibiotic use1-3,34


The ASSIGN trial shows that Neocate Syneo brings the gut microbiota of allergic infants closer to that of healthy breastfed infants.1,2


  • There was a sustained improvement in the gut microbiota composition of allergic infants over 26 weeks.1,2 Evidenced by a significant growth of Bifidobacterium in line with levels seen in healthy breastfed infants and the competitive inhibition of pathogenic bacteria1,2
  • Certain species of microbes, such as Bifidobacteria, support the development of the immune system and promote oral tolerance4,5

Exploratory outcomes from research show that infants receiving Neocate Syneo exhibit a reduction in infections1–3 as well as antibiotic1,2 use.

Fewer infections

Exploratory outcomes from research shows that infants receiving Neocate Syneo exhibit a reduction in infections as well as antibiotic use, compared to infants receiving a regular AAF without synbiotics.1–3

Nutricia have reduced the price of Neocate Syneo, making the unique benefits of synbiotics more accessible to your infants with CMA


For more information contact your local representative using our contact form below 

Contact us

Order your free sample* of Neocate Syneo

Giving you the flexibility to order product samples and have them sent to you or directly to your patients’ homes Register / Login to order

*Product can be provided to patients upon the request of a Healthcare Professional. They are intended for the purpose of professional evaluation only.

Important notice: Breastfeeding is best. Neocate Syneo is a food for special medical purposes for the dietary management of Cow’s Milk Allergy, Multiple Food Protein Allergies and other conditions where an amino acid based formula is recommended. It should only be used under medical supervision, after full consideration of the feeding options available including breastfeeding. Suitable for use as the sole source of nutrition for infants under one year of age. Refer to label for details.

  1. Candy DCA et al. Pediatr Res. 2018;83(3):677-86.
  2. Fox AT et al. Clin Transl Allergy. 2019;9:5.
  3. Burks AW et al. Ped Allergy Immunol. 2015;26:316-22.
  4. Martin R et al. Benef Microbes. 2010;1(4):367-82.
  5. Wopereis H et al. Pediatr Allergy Immunol. 2014;25:428-38.
  6. Harvey BM et al. Pediatr Res. 2014;75:343-51.
  7. WHO. Infant and young child feeding. 2003.
  8. Jeurink PV et al. Benef Microbes. 2013;4(1):17-30.
  9. Weng M et al. J Dev Orig Health Dis. 2013;4(3):203-14.
  10. Boehm G et al. J Nutr. 2007;137:8475-95.
  11. Moossavi S et al. Front Pediatr. 2018;6:197.
  12. Kull I et al. Arch Dis Child. 2002;87:478-81.
  13. Matheson MC et al. J Allergy Clin Immunol. 2007;120(5):1051-57.
  14. Scholtens PA et al. Annu Rev Food SciTechnol. 2012;3:21.1:21-23.
  15. Hunt KM et al. PLoS ONE. 6(6): e21313. doi:10.1371.
  16. Li M et al. Semin Reprod Med. 2014;32:74–86.
  17. Kaplan JL et al. Pediatr Res. 2011;69:465–72.
  18. Kirjavainen PV. Gut. 2002;51:51–55.
  19. Huang YJ et al. J Allergy Clin Immunol. 2017;139(4):1099-1110.
  20. Azad MB et al. Clin Exp Allergy. 2015;45:632-43.
  21. Bisgaard H et al. J Allergy Clin Immunol. 2011;128:646-52.e1-5.
  22. Abrahamsson TR et al. J Allergy Clin Immunol. 2012;129:434-40,40.e1-2.
  23. Kunz C et al. AnnuRev Nutr. 2000;20:699-722.
  24. Knol J. J Pediatr Gastroenterol Nutr. 2005;40(1):36-42.
  25. Moro G. J Pediatr Gastroenterol Nutr. 2002;34(3):291-5.
  26. Taniuchi S et al. The Journal of Applied Research. 2005;5(2):387-396.
  27. Soto A et al. J Pediatr Gastroenterol Nutr. 2014;59(1):78–88.
  28. Thompson-Chagoyan OC et al. Pediatr Allergy Immunol. 2010;21:e394-400.
  29. Mikami K et al. Pharmaceuticals. 2012;(5)629-42.
  30. Inoue Y et al. Biol Pharm Bull. 2009;32(4):760–63.
  31. Hougee S et al. Int Arch Allergy Immunol. 2010;151(2):107–17.
  32. Van Esch B et al. Immun Inflamm Dis. 2016;4(2):155–65.
  33. Hattori K et al. Arerugi. 2003;52(1):20–30.
  34. Chatchatee P et al. 2019 Abstract at EAACI PAAM.
  35. Commission Delegated Regulation (EU) 2016/128 (FSMP) and Commission Delegated Regulation (EU) 2016/127 (the specific compositional and information requirements for infant formula and follow-on formula)

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