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Aptamil Comfort's ingredients, clinical evidence, parent and Healthcare Professional feedback

IMPORTANT NOTICE: Breastfeeding is best. Aptamil Comfort is a food for special medical purposes for the dietary management of colic & constipation. It should only be used under medical supervision, after full consideration of the feeding options available including breastfeeding. Suitable for use as the sole source of nutrition for infants from birth and as part of a balanced diet from 6-12 months. Refer to label for details.


Aptamil Comfort's tailored ingredients

Aptamil Comfort has a tailored combination of ingredients to support GI health and promote a healthy gut microbiota for the dietary management of colic and constipation


Tailored fat blend with high levels of beta-palmitate may help to promote softer stools and aid the absorption of fat and calcium1–3


Partially hydrolysed whey protein for easy digestion and reduced gastrointestinal transit time4,5


Prebiotic oligosaccharides – short chain Galacto-oligosaccharides and long chain Fructo-oligosaccharides (scGOS:lcFOS) (9:1) supports a healthy gut microbiota by increasing the number of beneficial bacteria and reducing harmful bacteria6,7


Reduced lactose can help to reduce flatulence and abdominal discomfort8


Large pool of clinical evidence

Aptamil Comfort benefits from a large pool of clinical evidence with proven efficacy for the management of colic, constipation and related symptoms.

Reference Study design & population Groups Study period Outcomes (Comfort vs. control)
Veitl et al. 2000 RCT with infants < 3 month with at least one of the following symptoms: excessive crying, constipation (with or without cramps), and general abdominal distress  Comfort (n=34) Control (n=17) 2 weeks
  • Less abdominal distress (after 1 and 2 weeks)  
  • Less constipation (after 2 weeks) 
  • Less crying (after 1 week)
Schmelzle et al. 2003 RCT with healthy term infants < 2 weeks Comfort (n=49) Control (n=53)  10 weeks
  • Softer stools
  • Higher proportion of bifidobacteria in the stool
Savino et al. 2003 Prospective observational study with infants < 3 months infantile colic and/or constipation  Comfort (n=604) 2 weeks
  • Less infantile colic
  • Less constipation
  • Positive judgements from parents (91%) and paediatricians (95%)
Savino et al. 2005 RCT with infants < 4 months with infantile colic Comfort (n=55) Control (n=40) 2 weeks
  • More frequent stools (after 1 week)
Savino et al. 2006 RCT with infants < 4 months with infantile colic Comfort (n=103) Control (n=93) 2 weeks
  • Less infantile colic (after 1 week)
Bongers et al. 2007 RCT (cross-over design) with infants 3-10 weeks with constipation Comfort (n=38) Control (n=38) 6 weeks 
  • Softer stools


Proven Efficacy



Rated by parents and healthcare professionals

Aptamil Comfort provides HCP & Parental satisfaction*


*based on an observational study conducted in Italy, with 604 infants. Adapted from Savino et al. 2003

  1. Havlicekova Z et al. Nutr J. 2016;15:28.
  2. Carnielli VP et al. Am J Clin Nutr. 1995;61:1037–1042.
  3. Kennedy K et al. The American Journal of Clinical Nutrition. 1999;70.5: 920–927.
  4. Billeaud C et al. Eur J Clin Nutr. 1990;44(8):577–583.
  5. Tolia V et al. J Pediatr Gastroenterol Nutr. 1992;15(3):297–301.
  6. Knol J et al. J Pediatr Gastroenterol Nutr. 2005;40(1):36–42.
  7. Moro G et al. J Pediatr Gastroenterol Nutr. 2002; 34(3):291–295.
  8. Kanabar D et al. J Hum Nutr Diet. 2001;14:359–363.
  9. Veitl et al. Ernährungsmed. 2000;2:14–20.
  10. Schmelzle H et al. J Pediatr Gastroenterol Nutr. 2003;36(3):343–351.
  11. Savino et al. Acta Paediatr Suppl. 2003;91:86–90.
  12. Savino et al. Acta Paediatr Suppl. 2005;94:120–124.
  13. Savino F et al. Eur J Clin Nutr. 2006;60:1304–1310.
  14. Bongers et al. Nutr J. 2007;6:8.
  15. Scholtens PA et al. World J Gastroenterol. 2014;20(37):13446–13452.

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