How does Souvenaid work?

Souvenaid is a medical nutrition product that contains a unique patented combination of nutrients designed to support synapse formation in early Alzheimer's disease19

Souvenaid - a nutritional approach in early Alzheimer's disease

Souvenaid is a medical nutrition product that contains a unique, patented combination of nutrients designed to support synapse formation. Souvenaid, addresses the specific nutritional requirements of the Alzheimer's disease patient19.

Synapse loss in Alzheimer's disease

Compared to other hallmarks of Alzheimer's disease, synapse loss corrrelates best with impaired memory1-3. Synapses are continuously being remodelled, and synapse formation depends on the production of neuronal membranes, which primarly consist of phospholipds4,5.

Fortasyn Connect™ - providing the nutritional components for synapse formation

The unique combination of nutritional precursors and cofactors in Souvenaid is known under the name Fortasyn Connect. These components work together to enhance phospholipid synthesis via the Kennedy pathway6-16 (Figure 1), and include specific precursors of phosphatidylcholine, the most abundant phospholipid in the brain:

  • Long chain omega-3 polyunsaturated fatty acids (PUFAs) - docosahexaenoic acid (DHA) and eicosapentaenoic (EPA)
  • Uridine supplied as uridine monophosphate (UMP)
  • Choline

Fortasyn Connect also contains the following cofactors, all of which synergistically enhance bioavailability of the aforementioned three main precursors to enhance phospholipid synthesis:

  • B vitamins
  • Phospholipids
  • Vitamin E
  • Vitamin C
  • Selenium

Figure 1: The biochemical pathway for synthesising new neuronal membranes

Souvenaid synthesising new neuronal membranes image
Adapted from Ritchie CW et al (2014)

The increased phospholipid synthesis supports the formation of neuronal membranes9. Preclinical models combining these nutritional precursors have demonstrated neurite outgrowth, increased dendritic spines density, increased levels of pre- and post-synaptic proteins, and improved learning6,8,12-13,17-18.

  1. Terry RD, et al. Physical basis of cognitive alterations in Alzheimer’s disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol, 1991; 30: 572-580.
  2. Terry RD. Alzheimer’s disease and the aging brain. J Geriatr Psychiatry Neurol, 2006; 19: 125-128.
  3. Scheff SW, et al. Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging, 2006; 27: 1372-1384.
  4. Yi JJ and Ehlers MD. Ubiquitin and protein turnover in synapse function. Neuron, 2005; 47: 629-632.
  5. Kennedy EP and Weiss SB. The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem, 1956; 222: 193-214.
  6. Wurtman RJ, et al. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res, 2006; 1088: 83-92.
  7. Cansev M, et al. Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson’s disease. Neurosci Res, 2008; 62: 206-209.
  8. Sakamoto T, et al. Oral supplementation with docosahexaenoic acid and uridine-5′-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res,  2007; 1182: 50-59.
  9. Holguin S, et al. Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats.Behav Brain Res, 2008; 191: 11-16.
  10. Holguin S, et al. Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. FASEB J., 2008; 22: 3938-3946.
  11. Cansev M, et al.  Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups. Dev Neurosci., 2009; 31: 181-192.
  12. Cansev M and Wurtman RJ. Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils. Neuroscience, 2007; 148: 421-431.
  13. Wang L, et al. Dietary supplementation with uridine-5′-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat. Brain Res., 2007; 1133: 42-48.
  14. Richardson UI, et al. Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells. Brain Res., 2003; 971: 161-167.
  15. Richardson UI and Wurtman RJ. Polyunsaturated fatty acids stimulate phosphatidylcholine synthesis in PC12 cells. Biochim Biophys Acta., 2007; 1771: 558-563.
  16. van Wijk N, et al. Plasma choline concentration varies with different dietary levels of vitamins B6, B12 and folic acid in rats maintained on choline-adequate diets. Br J Nutr., 2012; 107: 1408-12.
  17. Ulus IH, et al. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release.Cell Mol Neurobiol., 2006; 26: 563-577.
  18. Pooler AM, et al. Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12. Neuroscience, 2005; 134: 207-214.
  19. Ritchie, CW et al Souvenaid: A new approach to management of early Alzheimer’s disease. The journal of nutrition, health & aging, 2014; 18(3): 291-299.
  20. Scheff et al. Journal of Alzheimer’s Disease, 2006; Vol 9,.
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  50. Lopes da Silva et al. Alheimers Dement, 2013.

Souvenaid is a Food for Special Medical Purposes for the dietary management of early Alzheimer's disease and must be used under medical supervision.

 

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