Compared to other hallmarks of Alzheimer's disease, synapse loss corrrelates best with impaired memory1-3. Synapses are continuously being remodelled, and synapse formation depends on the production of neuronal membranes, which primarly consist of phospholipds4,5.
The unique combination of nutritional precursors and cofactors in Souvenaid is known under the name Fortasyn Connect. These components work together to enhance phospholipid synthesis via the Kennedy pathway6-16 (Figure 1), and include specific precursors of phosphatidylcholine, the most abundant phospholipid in the brain:
Fortasyn Connect also contains the following cofactors, all of which synergistically enhance bioavailability of the aforementioned three main precursors to enhance phospholipid synthesis:
The increased phospholipid synthesis supports the formation of neuronal membranes9. Preclinical models combining these nutritional precursors have demonstrated neurite outgrowth, increased dendritic spines density, increased levels of pre- and post-synaptic proteins, and improved learning6,8,12-13,17-18.