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Patient & Carers
Ireland
Patient & Carers
Ireland

Nutriprem range

The nutriprem range is specifically tailored to help meet the nutritional needs of preterm and low birth weight infants, including specialised formulas, protein supplement and human milk fortifier. 

About Nutriprem

 

Nutriprem range

Cow & Gate nutriprem Human milk Fortifier

Cow & Gate nutriprem Human milk Fortifier

Contains additional energy and nutrients for human milk fed preterm infants. Developed for preterm infants weighing 1-1.8kg. Contains: extensively hydrolysed protein with a 50:50 whey:casein ratio; carbohydrates; vitamins & minerals.

Cow & Gate nutriprem Protein Supplement

Cow & Gate nutriprem protein supplement

Designed specifically to help meet the increased protein requirements of preterm infants weighing <1kg. Can be added to breast milk fortified with nutriprem HMF, nutriprem 1 or hydrolysed nutriprem. Contains extensively hydrolysed protein with a 50:50 whey:casein ratio.

Cow & Gate nutriprem 1

Cow & Gate nutriprem 1

Contains 80kcal per 100ml and the nutrients needed for preterm and low birthweight infants in a small volume. Developed for preterm infants weighing 1-1.8kg. Sterile ready-to-feed 70ml bottle. Contains: prebiotic oligosaccharides; milk fat; long-chain polyunsaturated fatty acids (LCPs).

Cow & Gate Hydrolysed nutriprem

Cow & Gate hydrolysed nutriprem

The UK’s only extensively hydrolysed preterm low birthweight formula. Suitable for preterm babies not tolerating standard preterm formulas. Developed for preterm infants weighing 1-1.8kg. Sterile ready-to-feed 90ml bottle. Contains: extensively hydrolysed formula with a 60:40 whey:casein ratio; milk fat; long-chain polyunsaturated fatty acids (LCPs).

Cow & Gate nutriprem 2 Post-Discharge Liquid (90ml)

Cow & Gate nutriprem 2 post-discharge liquid (90ml)

Developed for formula fed infants, bridging the nutritional gap between preterm/ low birthweight and term formulas. Sterile ready-to-feed 90ml bottle for in hospital use only, to support transition from preterm formula before discharge home. Contains: prebiotic oligosaccharides; milk fat; long-chain polyunsaturated fatty acids (LCPs).

Cow & Gate nutriprem 2 Post-Discharge Powder

Cow & Gate nutriprem 2 post-discharge powder

Developed for formula-fed preterm infants with a below-normal weight for post-conceptional age at discharge. Prescribable in the community up to six months corrected age, nutriprem 2 contains higher levels of nutrients than standard term milks to help support catch up growth after discharge. Contains: prebiotic oligosaccharides; milk fat; long-chain polyunsaturated fatty acids (LCPs).

Cow & Gate nutriprem 2 Post-Discharge Liquid (200ml)

Cow & Gate nutriprem 2 post-discharge liquid (200ml)

Developed for formula-fed preterm infants with a below-normal weight for post-conceptional age at discharge. Prescribable in the community up to six months corrected age, nutriprem 2 contains higher levels of nutrients than standard term milks to help support catch up growth after discharge. Contains: prebiotic oligosaccharides; milk fat; long-chain polyunsaturated fatty acids (LCPs). Cow & Gate nutriprem 2 200ml is a sterile, ready to feed formulation which is suitable for infants who remain at increased risk of infection post discharge due to an immature immune system.

Importance of milk fat

Breast milk has a specific fatty acid profile containing high levels of ß-palmitate (palmitic acid in the ß-position). When palmitic acid is in the ß-position, fats are metabolised more efficiently by infants12.

This provides beneficial effects for the infant, including4-8:

  • Easier digestion
  • Softer stools
  • Better fat absorption
  • Improved calcium absorption 

Nutriprem 1, hydrolysed nutriprem and nutriprem 2 contain milk fat, which is naturally rich in ß-palmitate. 

Prebiotic Oligosaccharides (OS) improve gut health

One of the major differences between breastfed and formula-fed infants is the development of the intestinal flora.13

Non-digestible oligosaccharides that act like prebiotics in breast milk play an important role in the production of beneficial bacteria supporting gut intestinal flora development.14

Nutriprem 1 and nutriprem 2 are the only preterm products that contain a blend of prebiotic OS, which is proven to:

  • Increase beneficial bifidobacteria1
  • Decrease potentially pathogenic bacteria2
  • Reduce gastrointestinal transit time3
  • Decrease stool viscosity, resulting in softer stools3
  • Potentially improve enteral tolerance in very preterm infants15
Figure 1 – Preterm infants receiving a formula with prebiotic OS for 28 days had significantly higher levels of bifidobacteria in the gut, compared to the group receiving a formula without prebiotic OS (p=0.0008)
  1. Boehm G et al. Arch Dis Child Fetal Neonatal Ed 2002;86:F178-81.
  2. Knol J et al. Acta Paediatr 2005;94(449):31-3.
  3. Mihatsch W et al. Acta Paediatr 2006;95(7):843-8.
  4. Bar-Yoseph F et al. Prostaglandins Leukot. Essent. Fatty Acids 2013;89(4):139-43.
  5. Carnielli et al Am J Clin Nutr 1995;61(5):1037-1042.
  6. Carnielli et al. J Pediatr Gastroenterol Nutr 1996;23(5):553-560.
  7. Kennedy et al. Am J Clin Nutr 1999;70(5):920-7.
  8. Quinlan et al. Pediatr Gastroenterol Nutr 1995;20(1):81-90.
  9. Agostoni C et al. J Pediatr Gastroenterol Nutr. 2010;50(1):85–91.
  10.  Aggett P et al. J Pediatr Gastroenterol Nutr. 2006;42(5):596–603.
  11.  Doherty et al. Front Pediatr. 2018;20:6:91.
  12.  Innis S et al. Lipids. 1994;29(8):541–5.
  13.  Harmsen HJM et al. J Pediatr Gastroenterol Nutr 2000;30(1):61–7
  14. Groer MW, et al. Microbiome 2014;2:(38):1-8
  15. Modi N et al. Pediatr Res. 2010;68(5):440–5.

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IMPORTANT NOTICE: Breastfeeding is best. Nutriprem human milk fortifier, nutriprem protein supplement, hydrolysed nutriprem, nutriprem 1 and 2 are foods for special medical purposes for the dietary management of preterm and low birthweight infants. They should only be used under medical supervision, after full consideration of the feeding options available including breastfeeding. Hydrolysed nutriprem, nutriprem 1 and 2 are suitable for use as the sole source of nutrition for preterm and low birthweight infants. Refer to labels for details.

You may also be interested in

Understanding the nutritional needs of the preterm infant

Prebiotic oligosaccharides: supporting gut health in preterm infants – a guide for healthcare professionals

European guidelines for feeding preterm infants

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