Newborn screening (NBS) has reshaped the landscape of dietetic practice within inherited metabolic disorders.  This presentation outlines the evolution of the UK NBS programme, from early PKU testing to the current expanded panel including MCADD, MSUD, GA1, IVA, HCU and most recently, HT1. Highlighting its impact on early diagnosis, clinical outcomes and dietetic service delivery. Early identification of metabolic disorders has shifted dietitians’ roles towards early life intervention, rapid education for families, intensified monitoring and long-term management. The session also reviews BIMDG NBS guidelines and touches on the Generation Study. Finally, it considers how NBS aligns with the NHS 10-Year Plan, particularly in relation to prevention, health equity, and the integration of digital and genomic innovations.