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International wound management guidelines recognise latest emerging evidence1

"Providing high calorie, high protein, arginine, zinc, and antioxidant oral nutritional supplements for adults with a Category/Stage II or greater pressure injury who are malnourished or at a risk of malnutrition"



Cubitan demonstrates a significant reduction in PU area - at 4 and 8 weeks2

A randomised, controlled study conducted on 157 malnourished elderly patients, average age of 81, with PU grades II, III, and IV; institutionalised or home care based.


Cubitan: twice as many patients have complete healing by 8 weeks2


The OEST study demonstrates a significant reduction in pressure ulcer area with Cubitan1

  1. National Pressure Ulcer Advisory Panel (NPUAP), European Pressure Ulcer Advisory Panel (EPUAP). Prevention and treatment of pressure ulcers: clinical practice guideline. Washington DC: National Pressure Ulcer Advisory Panel; 2009.
  2. Harris CL. et al. Malnutrition in the institutionalized elderly: the effects on wound healing. Ostomy Wound Manage 2004; 50 (10):54-63.
  3. Scholl D. et al. Nutrient recommendations for wound healing. Journal of Intravenous Nursing 2001; 24 (2): 124-132
  4. Patel GK. et al. The role of nutrition in the management of lower extremity wounds. International Journal of Lower Extremity Wounds 2005; 4 (1): 12-22.
  5. Meyer NA. et al. Nutrient support of the healing wound. New Horiz. 1994; 2 (2): 202-214.
  6. Barbul A. et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery 1990; 108 (2): 331-336.
  7. Kirk SJ. et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993; 114: 155-160.
  8. Thompson C. et al. Nutrients and wound healing: still searching for the magic bullet. Nutrition in Clinical Practice 2005; 20 (3): 331-347.
  9. European Pressure Ulcer Advisory Panel, National Pressure Injury Advisory Panel and Pan Pacific Pressure Injury Alliance. Prevention and Treatment of Pressure Ulcers/Injuries: Quick Reference Guide. Emily Haesler (Ed.). EPUAP/NPIAP/PPPIA; 2019.
  10. OEST Study results; Data on file.
  11. Cereda E. et al. Disease-specific nutritional support in malnourished pressure ulcer patients: a randomized, controlled trial. Ann Intern Med 2015.
  12. Neyens J, Cereda E, Rozsos I et al. Effects of an arginine-enriched oral nutritional supplement on the healing of chronic wounds in non-     malnourished patients; a multicenter case series from The Netherlands and Hungary. J Gerontol Geriatr Res, 2017; 6(2).
  13. Cereda E, Neyens J, Caccialanza R et al. Efficacy of a disease-specific nutritional support for pressure ulcer healing: a systematic review and meta-analysis. J Nutr Health Ageing, 2017; 21(6): 655-661.

Cubitan is a Food for Special Medical Purposes for the dietary management of malnourished patients with chronic wounds and must be used under medical supervision.

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